These are some things I do think about when helping a customer with their shares:

Backups, The shares, Formating, Previous versions.

Backups

• Even if using previous versions, take backups.
• Test to restore a file here and there.
• Check how long you need to keep the backups.
• Dump the registry share incase of problems.

The shares

• If you are using DFS, share at the level of the DFS links.
• Hide the shares if you dont want users to map them.
• If the share is not supposed to be available offline, disable offline caching under the caching button.
• Dont complicate the share rights to much. You are using NTFS too.
• Remember shares grow plan for it.

Formating

• Format the drive with ≥16KB even if not using previous versions.
• Atleast format it with 8KB anything more than 4KB disables compression.
• When you initialize the disk use GPT you never know if might need to expand it past 2TB.
• Name your disks. I like to be able to see which drive_server_purpose, E_FILE01_Homedrives.

Everybody loves previous versions

• Remember to format your NTFS disk with ≥ 16KB NTFS clustersize. It is important.
• If this is a busy fileserver place the VSS copy on another disk.
• Talk to the endusers, when are the best times for the copies. A 24/7 might need more shadow copies.
• If clustering remember to bring the VSS copy disk online first using cluster requirements.
• Take extra care when playing with mountpoints.
• Dont do it to often, if you need that level look at DPM or other solution.

Remember to read my other post Plan a structure for Homedirectories and Redirected folders.